| Week | Date | Opponent | Time |
| 1 | Friday, August 13, 2021 | at Detroit | 7:00 PM |
| 2 | Saturday, August 21, 2021 | at Chicago | 1:00 PM |
| 3 | Saturday, August 28, 2021 | Green Bay | 1:00 PM |
| | | | |
| Week | Date | Opponent | Time |
| 1 | Sunday, September 12, 2021 | Pittsburgh | 1:00 PM |
| 2 | Sunday, September 19, 2021 | at Miami | 1:00 PM |
| 3 | Sunday, September 26, 2021 | Washington | 1:00 PM |
| 4 | Sunday, October 3, 2021 | Houston | 1:00 PM |
| 5 | Sunday, October 10, 2021 | at Kansas City | 8:20 PM |
| 6 | Monday, October 18, 2021 | at Tennessee | 8:15 PM |
| 7 | BYE | BYE | BYE |
| 8 | Sunday, October 31, 2021 | Miami | 1:00 PM |
| 9 | Sunday, November 7, 2021 | at Jacksonville | 1:00 PM |
| 10 | Sunday, November 14, 2021 | at N.Y. Jets | 1:00 PM |
| 11 | Sunday, November 21, 2021 | Indianapolis | 1:00 PM |
| 12 | Thursday, November 25, 2021 | at New Orleans | 8:20 PM |
| 13 | Monday, December 6, 2021 | New England | 8:15 PM |
| 14 | Sunday, December 12, 2021 | at Tampa Bay | 4:25 PM |
| 15 | Sunday, December 19, 2021 | Carolina | TBA |
| 16 | Sunday, December 26, 2021 | at New England | 1:00 PM |
| 17 | Sunday, January 2, 2022 | Atlanta | 1:00 PM |
| 18 | Sunday, January 9, 2022 | Jets | 1:00 PM |
